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( a ) Alpha diversity of intestinal <t>microbiota</t> including Shannon, Simpson, Chao1 and ACE of baseline and end in the placebo and intervention group. ( b ) The principal coordinate analysis (PCoA) performing on Bray-Curtis distances among intestinal microbiota before and after intervention in two groups. LEfSe multilevel discriminant analysis of species differences (LDA > 1.0) ( c ) in the HCP group before and after the intervention, and ( d ) between the two groups after the intervention. n = 19 in the test product group (HCP); n = 20 in the placebo group. Placebo_BL: the baseline of the placebo group; Placebo_END: the endpoint of the placebo group; HCP_BL: the baseline of the HCP group; HCP_END: the endpoint of the HCP group.
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( a ) Alpha diversity of intestinal <t>microbiota</t> including Shannon, Simpson, Chao1 and ACE of baseline and end in the placebo and intervention group. ( b ) The principal coordinate analysis (PCoA) performing on Bray-Curtis distances among intestinal microbiota before and after intervention in two groups. LEfSe multilevel discriminant analysis of species differences (LDA > 1.0) ( c ) in the HCP group before and after the intervention, and ( d ) between the two groups after the intervention. n = 19 in the test product group (HCP); n = 20 in the placebo group. Placebo_BL: the baseline of the placebo group; Placebo_END: the endpoint of the placebo group; HCP_BL: the baseline of the HCP group; HCP_END: the endpoint of the HCP group.
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( a ) Alpha diversity of intestinal <t>microbiota</t> including Shannon, Simpson, Chao1 and ACE of baseline and end in the placebo and intervention group. ( b ) The principal coordinate analysis (PCoA) performing on Bray-Curtis distances among intestinal microbiota before and after intervention in two groups. LEfSe multilevel discriminant analysis of species differences (LDA > 1.0) ( c ) in the HCP group before and after the intervention, and ( d ) between the two groups after the intervention. n = 19 in the test product group (HCP); n = 20 in the placebo group. Placebo_BL: the baseline of the placebo group; Placebo_END: the endpoint of the placebo group; HCP_BL: the baseline of the HCP group; HCP_END: the endpoint of the HCP group.
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Image Search Results


( a ) Alpha diversity of intestinal microbiota including Shannon, Simpson, Chao1 and ACE of baseline and end in the placebo and intervention group. ( b ) The principal coordinate analysis (PCoA) performing on Bray-Curtis distances among intestinal microbiota before and after intervention in two groups. LEfSe multilevel discriminant analysis of species differences (LDA > 1.0) ( c ) in the HCP group before and after the intervention, and ( d ) between the two groups after the intervention. n = 19 in the test product group (HCP); n = 20 in the placebo group. Placebo_BL: the baseline of the placebo group; Placebo_END: the endpoint of the placebo group; HCP_BL: the baseline of the HCP group; HCP_END: the endpoint of the HCP group.

Journal: Scientific Reports

Article Title: ACE inhibitory casein peptide lowers blood pressure and reshapes gut microbiota in a randomized double blind placebo controlled trial

doi: 10.1038/s41598-025-98446-6

Figure Lengend Snippet: ( a ) Alpha diversity of intestinal microbiota including Shannon, Simpson, Chao1 and ACE of baseline and end in the placebo and intervention group. ( b ) The principal coordinate analysis (PCoA) performing on Bray-Curtis distances among intestinal microbiota before and after intervention in two groups. LEfSe multilevel discriminant analysis of species differences (LDA > 1.0) ( c ) in the HCP group before and after the intervention, and ( d ) between the two groups after the intervention. n = 19 in the test product group (HCP); n = 20 in the placebo group. Placebo_BL: the baseline of the placebo group; Placebo_END: the endpoint of the placebo group; HCP_BL: the baseline of the HCP group; HCP_END: the endpoint of the HCP group.

Article Snippet: Sequencing of the 16S rRNA-amplified fragments (v3-v4 from the fecal microbiota of the participants was performed by Beijing Biomarker Technologies Co. Ltd. Barcoded specific bacterial primers was used for PCR amplification: forward primer 5’- ACT CCT ACG GGA 210 GGC AGC A-3’ and reverse primer 5’-GGA CTA CHV GGG TWT CTA AT-3’).

Techniques: